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Frank Sawyer, 'Lost'
Christina Yang, 'Grey's Anatomy'
Lewis Black, 'The Daily Show with Jon Stewart'
Chloe, '24'
Dr. Gregory House, 'House'
Dr. Perry Cox, 'Scrubs'
Tommy Gavin, 'Rescue Me'
Eric Cartman, 'South Park'
Al Swearengen, 'Deadwood'
Bill Bittinger, 'Buffalo Bill'
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4. Denis Leary as Tommy Gavin, 'Rescue Me'

From his scathing stand-up comedy to the too-soon canceled "The Job" to the superb "Rescue Me," Leary never sanitizes his tough-as-nails persona of trash-talking, screwed-up Irish working stiff. In "Rescue Me," his NY firefighter boozes, drugs and womanizes himself to the edge and back, haunted by ghosts from 9/11, his shattered family and ... a hard-partying Jesus. Somehow, Leary mines saving humor from this acid-tongued loser. He hits bottom when, in drunken despair, he drenches himself in vodka and starts to flick his Bic. But even on his best days, Tommy is still a flayed soul, halfway along the road to hell.

Next: Eric Cartman, 'South Park'
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