ER

George Clooney, Dr. Doug Ross

We've been keeping tabs on the crinkly-smiled, pediatric doc-turned-movie star ever since his final appearance at the end of Season 5. Can you blame us? Clooney has become one of Hollywood's most acclaimed leading men. (Did we mention he's been ... morePeople magazine's "Sexiest Man Alive"-- twice?) From "The Perfect Storm" and the "Ocean's Eleven" franchise, Clooney earned a 2005 Academy Award for writing in "Good Night, and Good Luck," and an Oscar nomination for acting in 2007's "Michael Clayton." His most recent film, "Leatherheads," was released last year. As if things couldn't get any better, Clooney has just been asked if he'd allow a vial of his sweat to be reproduced as a tofu flavor. Yum!

(Theodore Wood/Camera Press/Retna Ltd.)