Izzie ponders whether to have a risky procedure; a patient prompts Owen to reassess his place at Seattle Grace; George... Full summary

Izzie decides on whether to have cancer surgery; Mark prepares to move forward with Lexie; Owen makes a reassessment.... Full summary

As Meredith and Derek's wedding nears, college students are rushed to the ER following a car crash on their way to... Full summary

Izzie's mother (Sharon Lawrence), who's something of a handful, shows up at Seattle Grace, while Meredith and Lexie... Full summary

Izzie won't let her taxing cancer treatments stop her from helping to plan Meredith and Derek's wedding. Meanwhile,... Full summary

While Derek prepares to perform his first surgery since his breakdown, Izzie must undergo one. Meanwhile, Owen has... Full summary

While Mark attempts a face-transplant surgery, Meredith tries to get Derek to return to work after his fellow surgeons... Full summary

Derek decides to quit after learning of a high mortality rate among his patients; Bailey and the chief continue to... Full summary

Derek's confidence is shaken when he and Addison (Kate Walsh) disagree on treatment for a pregnant woman who's dying;... Full summary

In a Private Practice crossover episode, Addison, Naomi and Sam rush Addison's ailing brother, Archer (Grant Show), to... Full summary