3 to 1: Most Vulnerable to the Grim Reaper

Charlie (Dominic Monaghan) : His plotlines have been pretty limited, especially since the demise of Mr. Eko. He's also an audience fave, so there'd be some shock value, though the real-life romance between Monaghan and Evangeline Lilly (Kate) might have producers thinking twice about alienating their leading lady.

Claire (Emilie de Ravin): Adorable, but she's done her job by having her baby on the island, don't you think?

Sun (Yunjin Kim): This would hurt, because there's a lot of her backstory that could affect Jin, Michael and the rest of the cast. Plus, her sensitivity, nuance, bilingualism and sailing abilities are all things the other cast members -- and we -- would miss. And then there's the baby. Just the kind of expectations producers like to dash.

Juliet (Elizabeth Mitchell): Please? We already can't stand her. She's the Goebbels-as-demented-cheerleader to Ben's Hitler.

Alex (Tania Raymonde): She looked like a goner at the end of Episode 6, anyway, though we'll feel cheated if it's only Alex, since she wouldn't really be considered a "major character."

Sawyer (Josh Holloway): This is a wild-card, but think about it. It'd be shocking, it would make Kate reel in unforeseen directions (back to Jack? away from everyone?) and it would reinforce one of "Lost's" early cardinal (carnal) rules: Have sex. Die.

5 to 1: Safe -- for Now

Hurley (Jorge Garcia): He's the Everyman the fans adore, so they won't mess with him ... for now. But his role as the island's geek-Greek chorus may not be needed indefinitely. Dude.

Jack (Matthew Fox): Yeah, Fox has been an ingrate in recent interviews, and producers have already suggested Jack will be missing from "several" episodes of the remainder of Season 3. It's probably because the storyline will be returning to the "main" island and not to the Alcatraz prison where Jack, Kate and Sawyer have been held captive. Plus, they want to tantalize us with the Jack-Kate unrequited thing.

Jin (Daniel Dae Kim): We'd hate to see it happen, but it could result in interesting character development of Sun (producers would never take them both).

Walt and/or Michael (Malcolm David Kelley/Harold Perrineau): If they come back, which they surely will, these two are fairly safe. The shock value of offing the only kid would be huge, and Michael may have more people from both camps after him after his betrayals. (A side note: What about Vincent? Why does that dog always look borderline fat? It can't be because he's feasting on rotting bones in the jungle -- or can it?)

15 to 1: Safe for Another Season or Two

Ben/Henry Gale (Michael Emerson): He's too deliciously Snidely Whiplash-ey to be done in just yet. Unless ... the mysterious Jacob, the mastermind behind the even more mysterious "list," is the real ringleader and we're about to be introduced to someone even more nefarious.

Locke (Terry O'Quinn): Survival skills, personal demons galore, the philosopher of the group -- he'll be around for a while longer. Let's hope his legs don't give out again.

Sayid (Naveen Andrews): OK, there's no real reason Sayid needs to stay indefinitely, other than he's such a hottie, not to mention a cool character. Plus, we have to believe there's going to be occasions for deliberate torture from time to time.

Kate (Evangeline Lilly): We predict the sweat-slicked beauty is going to be with us for a while, as it becomes clear she's the sun around which most of the planets circle. As the series' central love object, she can't be easily replaced and, besides, we're still learning her creepy backstory (way to blow up your dad, Monica).