In the skit, the actress interrupts the host's shower at the beginning of the show to criticize her "sham" show and deliver a harsh message from TV mogul Oprah Winfrey. As both naked stars stand face to face, their breasts pixelated, Bullock snarls, "You have a responsibility to be a respectable talk show host. This comes directly from Oprah's mouth to my ear, to my mouth, out of my mouth, into your ear, down your body. ... The overall theme of this message is that you are a huge disappointment. ... You have a responsibility to be a role model to young girls ... and you need to lay off the booze." Slapping a stunned Handler, Bullock also urged the talk show host, who briefly romanced 50 Cent, to "stop sleeping with your guests," adding, "That is why I've not done your show; I do not wanna sleep with you."
Protesting, Handler said, "I don't sleep with that many anymore -- I mean, just some of the rappers," prompting Bullock to slap her again. Later during the show, Handler said, "I was the only one who was really naked. ... Sandy's like, 'You can put a thong on and pasties.'"
Bullock wasn't the only big Hollywood name to make an appearance on Handler's show from her Universal Studios home -- best pal Jennifer Aniston was her first guest. The former "Friends" star gave her pal an empty water container, explaining, "You're a big girl now. ... Every time you swear or sleep with a guest, you have to put money in that thing and then you want to fill it up ... and then you're gonna give it to St. Jude's Children's Research Hospital." Handler joked, "That means they're gonna get, like, a donation tomorrow."